Divide bison into four portions. Form into balls, then pat gently into patties slightly larger than diameter of your burger buns. Press a shallow divot into the center of the burger.
Season both sides of the burgers with salt and pepper, then set aside on a flat plate or tray while you heat your stovetop pan or grill to medium.
Cook for 3-4 minutes per side. If using cheese, place on burgers in last two minutes of cooking.
Serve with your favorite burger toppings.
Notes
This makes 4 4-ounce burgers, but if you like larger burgers, feel free to divide the meat into larger portions.